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KMID : 0604520090350020117
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Journal of the Society of Cosmetic Scientists of Korea
2009 Volume.35 No. 2 p.117 ~ p.123
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Inhibition of Adipogenesis in 3T3-L1 Adipocytes with Magnolia officinalis Extracts
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Kim Hyun-Joo
Lee Yeo-Myeong
Kim Yeon-Hyang
Won Sun-Im
Choi Sung-A
Choi Shin-Wook
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Abstract
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Magnolia extract, prepared from the Chinese herb Magnolia officinalis, is known for its potent anti-oxidative and anti-inflammatory effects. In this report, we showed that Magnolia extract inhibits adipocyte differentiation, as evidenced by reduced triglyceride (TG) accumulation. Also, Magnolia extract increased hormone sensitive lipase (HSL) protein level, and decreased the adipogenic transcription factor peroxisome proliferator activated receptor (PPAR)-γ protein and their corresponding mRNA. Our results suggest a potential apllication of Magnolia extract as anti-obesity agents inhibits adipocyte differentiation through the down-regulation of adipogenic transcription factors and other adipocyte-specific genes.
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KEYWORD
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Magnolia officinalis, 3T3-L1 cell, adipocytes differentiation, peroxisome proliferator activated receptor-γ, hormone sensitive lipase
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